Azelastine is a spray administered through the nasal passages

     Astelin contains Azelastine hydrochloride as an active ingredient. Astelin is an antihistamine which is designed for treating allergy symptoms such as sneezing and itchy, runny nose. It is also used to treat symptoms of nasal passage inflammation such as runny nose, stuffy nose, and postnasal drip. 

Mechanism of action:

     Histamine can produce symptoms of itching, sneezing, watery eyes, and runny nose. Astelin works by blocking the action of histamine, which reduces allergy symptoms.

Precautions:

• Take exactly as prescribed by your physician. 
• Do not take in larger or smaller amounts or for longer than recommended.
• Consuming alcohol can increase certain side effects of azelastine.
• Do not use this medication if you are allergic to azelastine.
• Discus with your physician if you are pregnant or plan to become pregnant while using this medication. It can harm an unborn baby.
• Do not take this medication without discussing with your physician if you are breast-feeding a baby.
• Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Astelin Side effects:

Get emergency medical help if you have any of these symptoms:

• rapid heartbeat
• hives 
• troubled breathing 
• tightness in the chest 
• swelling of your face, lips, tongue, or throat
• Blood in the urine

Common side effects are:

• Bitter taste in the mouth
• Nosebleeds
• drowsiness or sleepiness
• headache
• dizziness, nausea
• weight gain
• sore throat

Storage: Astelin should store at room temperature between 20 and 25 degrees C and away from light, heat and moisture. Do not freeze it. Keep it out of the reach of children and away from pets.


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Astelin the effects of natural chemical histamine in the body

Astelin which contain Azelastine is a potent, second-generation, selective, histamine antagonist (histamine-H1-receptor antagonist). According to the Allergic Rhinitis and its Impact on Asthma (ARIA) treatment guidelines, intranasal anti-histamines are recommended for the first line therapy of mild intermittent, moderate/severe intermittent and mild persistent rhinitis (new classification system for rhinitis).

Indications and Usage
Treatment of symptoms of seasonal allergic rhinitis, such as rhinorrhea, sneezing, and nasal pruritus (nasal spray); treatment of symptoms of vasomotor rhinitis, such as rhinorrhea, nasal congestion, and postnasal drip ( Astelin only); treatment of symptoms of perennial allergic rhinitis ( Astepro only); treatment of itching of eye associated with allergic conjunctivitis (ophthalmic).

Mechanism of action:
Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.

Side effects:

• Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
• Stop using azelastine and call your doctor at once if you have any of these serious side effects:
• bronchospasm (shortness of breath, tightness in chest, wheezing); or
• fast or uneven heartbeats.

Less serious side effects may include:

• a bitter taste in your mouth;
• headache;
• drowsiness or dizziness;
• dry mouth, sore throat;
• burning in your

Storage:
Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

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