Astelin the effects of natural chemical histamine in the body

Astelin which contain Azelastine is a potent, second-generation, selective, histamine antagonist (histamine-H1-receptor antagonist). According to the Allergic Rhinitis and its Impact on Asthma (ARIA) treatment guidelines, intranasal anti-histamines are recommended for the first line therapy of mild intermittent, moderate/severe intermittent and mild persistent rhinitis (new classification system for rhinitis).

Indications and Usage
Treatment of symptoms of seasonal allergic rhinitis, such as rhinorrhea, sneezing, and nasal pruritus (nasal spray); treatment of symptoms of vasomotor rhinitis, such as rhinorrhea, nasal congestion, and postnasal drip ( Astelin only); treatment of symptoms of perennial allergic rhinitis ( Astepro only); treatment of itching of eye associated with allergic conjunctivitis (ophthalmic).

Mechanism of action:
Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.

Side effects:

• Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
• Stop using azelastine and call your doctor at once if you have any of these serious side effects:
• bronchospasm (shortness of breath, tightness in chest, wheezing); or
• fast or uneven heartbeats.

Less serious side effects may include:

• a bitter taste in your mouth;
• headache;
• drowsiness or dizziness;
• dry mouth, sore throat;
• burning in your

Storage:
Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

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